Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage is defined when three consecutive pregnancy losses happen prior to 20 weeks from the last menstrual cycle.
Treatment of RPL involves diagnostic investigation and therapeutic intervention that requires knowledge and expertise in the subject, like, the risk factors associated with subsequent fetal losses and the probability of finding a treatable aetiology for the disorder.
Some of the probable causes of the disorder include:
- Parental chromosomal abnormalities
- Untreated hypothyroidism
- Uncontrolled diabetes mellitus
- Certain uterine anatomic abnormalities
- Anti-phospholipid Antibody Syndrome (APS)
- Additional endocrine disorders
- Heritable and/or acquired Thrombophilias
- Immunologic abnormalities and infections
- Environmental factors